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Fernando E. Kafie, M.D., F.A.C.S.
Web Sites:
Medical Director: Sacred Heart Vascular Access Center
Education:
U.C. Irvine B.S (June 1985-July '89)
U.C.L.A. M.D. (June 1989-July '93) UCLA School of Medicine
U.C. Irvine Gen Surgery (1993-'99) UCI Department of Surgery
U.C.L.A. Vasc Surgery (1999-2000) UCLA Vascular Surgery
Research Interest:
2003-2004 Investigator for an Imaging Study in Subjects comparing CTA’s to standard of care Angios.
2004-2005 Principal Investigator for a Phase II Double-Blind, Randomized, Placebo-Controlled Study to Improve
Perfusion in Critical Leg Ischemia.
2005-Present Investigator for Comparator Antibiotic Study for Subjects with Complicated Skin and Soft Tissue
Infections proven to be due to MRSA.
2006-Present Investigator for Double-Blind, Controlled Comparative Efficacy and Safety Study comparing Topical
Human Thrombin to Bovine Thrombin in Surgical Hemostasis.
2004-2005 Principal Investigator in a phase II, randomized, double-blind study of the efficacy or a topical thrombin in
patients undergoing peripheral arterial bypass surgery.
2004-2005 Principal Investigator in a phase II, randomized, double-blind study of the efficacy or a topical thrombin in
patients undergoing arterio-venous graft formation with synthetic.
2002-2005 Principal Investigator for a double-blind study for patients with Claudication.
2002-2004 Investigator for a open-label, phase IV clinical trial measuring wound healing rates.
2001-2002 Investigator for a randomized, open-label, phase IV clinical trial for the treatment of patients with
diabetic foot infections.
2001-2004 Investigator for a double-blind study in patients with critical limb ischemia who are candidates for
revascularization surgery.
2001-2004 Investigator for a double-blind study in patients with critical limb ischemia who are not candidates
for revascularization surgery.
Ancure (Guidant Corporation) Endovascular Graft
AneuRx (Medtronic Corporation) Endovascular Graft
Endovascular Grafting, UCLA School of Medicine
Endovascular Surgery for the Vascular Surgeon, UCLA School of Medicine
Florida Vascular Surgery Society
American College of Surgeons
Peripheral Vascular Surgery Society
Experience:
1) project: "Volume Reduction in Emphysematous Lungs"
description: Conduct thoracic volume reduction in emphysematous rabbit lungs with measurement of pre and post stapling pulmonary function tests.
Mentor: Matthew Brenner, M.D.2) project: "Blunt Intestinal Trauma"
description: Retrospective database analysis of trauma patients presenting to UCIMC from 1991-1995 with intestinal injury.
Mentor: Gail Tominaga, M.D., Kenneth Waxman, M.D.3) project: "The effects of topical Amikacin in the treatment of infected PTFE aortic grafts in a rabbit model"
description: Isolation of abdominal aortas in New Zealand rabbits and replacement with prostetic grafts (PTFE) to test the effects of topical Amikacin in graft infection.
Mentor: John Chen, M.D., Samuel E. Wilson, M.D.
1) project: "Isotropic light delivery devices for Photodynamic Therapy"
description: Design, build, and test light delivery devices for the treatment of cancers of the Head and Neck with Photodynamic Therapy.
Mentor: Richard Fabian, M.D. and Tayyaba Hasan Ph.D.2) project: "Small Cell CA of the Head & Neck"
description: Review patient files at the Mass Eye & Ear Infirmary for a retrospective study on Oat Cell CA of the H & N.
Mentor: Richard Fabian, M.D.-Undergraduate Research (UCI School of Medicine)
1) project: "Effects of Serotonin and Histamine on Coronary Artery Vasoactivity"
description: Isolate live Bovine coronary arteries and mount on perfusion apparatus using microsurgical techniques for subsequent measurements of vasoactivity in response to substances in question.
Mentor: M. Morcos, M.D.
Co-Investigator for AstraZeneca. Protocol # 839-02,-03,-04,-05. Double blind parallel placebo-controlled study of the safety and efficacy of Chronic Oral Beraprost Sodium in patients with intermittent claudication. July 2000-present.
Co-Investigator for Catalyst Pharmaceutical Research LLC. Protocol # WFI 01-02, IND # 53,867. Circulase. Double blind, randomized, placebo-controlled study to assess the efficacy and safety of circulase in conjunction with peripheral revascularization for the treatment of critical leg ischemia.
Co-Investigator for Pharmacia. Linezolid iv or po compared to Unasym iv or Augmentin po for the treatment of pats with diabetic foot infections-a randomized, open-label, phaze IV clinical trial.
F Kafie, D. J. Tessier, C. Theuer. Cytomegalovirus Colitis Mimicking Colon Carcinoma in an Immunocompetent Patient. Department of Surgery, University of California, Irvine.F Kafie, R. Williams, D.J. Tessier, M. Cinat, M. Lekawa, S.E. Wilson. Serial Abdominal Closure ("SAC") Technique: A Novel Method for Delayed Closure of the Abdominal Wall. The Journal of Trauma (in print).
M. Brenner, R. Yusen, R. McKenna, F. Sciurba, A. Gelb, R. Fischel, J. Swain, J. Chen, F. Kafie, S. Lefrak. Lung Volume Reduction Surgery for Emphysema. Chest 1996; 110:205-18.
Huh, J, M Brenner, JC Chen, B Yoong, A Gasses, T Waite, F Kafie, AF Wilson, JC Milliken, R McKenna, R Fischel, A Gelb, M Berns. (in review). Changes in Pulmonary Physiology After Lung Volume Reduction Surgery in a Rabbit Model of Emphysema. Journal of Thoracic & Cardiovascular Surgery.
Chen, JC, M Brenner, J Huh, B Yoong, A Gassel, T Waite, F Kafie, D Mukai, AF Wilson, JC Milliken, R McKenna, R Fischel, A Gelb, M Berns, E Stemmer. (in review). Effect of Lung Volume Reduction Surgery on Pulmonary Diffusion Capacity in a Rabbit Model of Emphysema. Journal of Thoracic & Cardiovascular Surgery.
Brenner, M., F. Kafie, B. Yoong, M. Budd, J. Chen, T. Waite, D. Mukai, N. Wang, R. McKenna, R. Fischel, A. Gelb, A. Wilson, M. Berns. (under review). The Effect of Lung Volume Reduction Surgery in a Rabbit Model of Bullous Lung Disease. Journal of Investigative Surgery.
Chen J., M Brenner, , F. Kafie, B. Yoong, M. Budd,, T. Waite, D. Mukai, N. Wang, R. McKenna, R. Fischel, A. Gelb, A. Wilson, M. Berns. (under review). An Animal Model of Lung Volume Reduction Therapy of Pulmonary Emphysema. Journal of Investigative Surgery.
Kafie, F, G Tominaga, B Yoong, K Waxman. Factors Related to Outcome in Blunt Intestinal Injuries Requiring Operation. American Journal of Surgery. 1997;63: 889-892.
J. Huh, J. Chen, G. Gurman, C. Malki, B. King, F. Kafie, S. Wilson. Local Treatment of Prosthetic Vascular Graft Infection with Multivesicular Liposome Encapsulated Amikacin. J Surg. Res. In Press.
Chen JC, Brenner M, Kafie F, Yoong B, Gassel A, Waite T, Milliken J, Huh J, Wang N, McKenna RJ, Gelb A, Wilson AF, Berns M. Animal Model for Lung Volume Reduction Therapy of Pulmonary Emphysema. Submitted to J Invest Surg, 1997.
Chen JC, Brenner M, Huh J, Yoong B, Gassel A, Kafie F, McKenna R, Gelb A, Stemmer EA, Wilson AF. Effect of Lung Volume Reduction Surgery on Pulmonary Diffusion Capacity in a Rabbit model. J Surg Res. In Press.
Brenner M, Kafie FE, Yoong B, Budd M, Chen JC, Waite TA, Milliken J, Huh J, Wang N, McKenna R, Gelb AF, Wilson AF, Berns MW. Dose Response in an Animal model for Lung Volume Reduction Therapy for Heterogenous Emphysema. Submitted, 1997.
Huh J, Brenner M, Chen JC, Yoong B, Gassel A, Waite T, Kafie F, Wilson AF, Milliken J, Stemmer E, McKenna R, Fischel R, Gelb A, Berns MW. Changes in Pulmonary Physiology after Lung Volume Reduction Surgery in a Rabbit Model of Emphysema. J Thor Cardiovascular Surg. In Press.
Kafie, F, M. Brenner. Fusion Lung Patch. Investigational Protocol. 1996.
F. Kafie, B. Wong. 1994. Small Cell Carcinoma of the Larynx: Case Report and Review of the Literature. American College of Surgeons.
Brenner, M, F. Kafie, J. Huh, M. Budd, B. Yoong, T. Waite, J. Chen, J. Milliken, J. Wong, R. McKenna, A. Gelb, M. Berns. 1997. The Effect of Lung Volume Reduction Surgery on Static Compliance in a Rabbit Model of Obstructive Pulmonary Disease. The Society of Thoracic Surgeons.
Brenner, M, F. Kafie, B. Yoong, M. Budd, , T. Waite, D. Mukai, R. McKenna, J. Chen, R. Fischel, A. Gelb, A. Wilson, M. Berns. 1996. The Effect of Lung Volume Reduction Surgery on Static Compliance and Maximal Flows in a Rabbit Model of Emphysema. Chest, 110, 177S, 1996.
Brenner, M, R. McKenna, R. Fischel, A. Gelb, F. Kafie, M. Budd, B. Yoong, J. Chen, A. Wilson, M. Berns. 1996. Assessment of Response in a Large Prospective Trial of Bilateral Stapled Lung Volume Reduction Surgery for Emphysema. Chest, 110, 49S, 1996.
Brenner, M, A. Gelb, R. McKenna, R. Fischel, F. Kafie, J. Chen, A. Wilson, M. Berns. 1996. Factors Associated with Improved Outcome in a Large Trial of Unilateral versus Bilateral Stapled Volume Reduction Surgery. Chest, 121.
Kafie, F., B. Yoong, K. Waxman, G.T. Tominaga (1997). Factors Related to Outcome in Blunt Intestinal Injuries Requiring Operation. American College of Surgeons.
Yoong, B., H. Wong, F. Kafie, T. Waite, J. Hyatt, C. Anderson, D. Mukai, R. McKenna, A. Gelb, A. Wilson, M. Berns, and M. Brenner. 1996. The Effect of Lung Volume Reduction Surgery on Static Compliance in a Rabbit Model of Bullous Emphysema. Biomedicine ë96, 44(3), 229S.
Kafie, F., M. Brenner, M. Budd, B. Yoong, J. Chen, E. Stemmer, M. Berns. 1996. Changes in Lung Compliance After Volume Reduction Surgery in a Rabbit Model of Bullous Emphysema. J Thorac Cardiovasc Surg, 112, 1413, 1996.
Yoong, B., H. Wong, F. Kafie, T. Waite, J. Hyatt, C. Anderson, D. Mukai, R. McKenna, A. Gelb, A. Wilson, M. Berns, and M. Brenner. 1996. The Effect of Lung Volume Reduction Surgery on Static Compliance in a Rabbit Model of Bullous Emphysema. Journal of Investigative Medicine, 44(1), 167A.
M. Brenner, R. McKenna, R. Fischel, A. Gelb, F. Kafie, M Budd, B. Yoong, J. Chen, A. Wilson, M. Berns. 1996. Assesment of Response in a large prospective trial of Bilateral Stapled Lung Volume Reduction Surgery for Emphysema. Chest, 1996.
M. Brenner, B. Yoong, M Budd, F. Kafie, T. Waite, D. Mukai, R. McKenna, J. Chen, R. Fischel, A. Gelb, A. Wilson, M. Berns. 1996. The effect of Lung Volume Reduction Surgery on Static Compliance and Maximal Flows in a Rabbit Model of Emphysema. Chest.
J. Chen, M. Brenner, J. Huh, F. Kafie, J. Milliken, B. Yoong, A. Gassel, E. Stemmer. 1997. Lung Reduction Surgery in a Rabbit Model of Obstructive Emphysema. Association of VA Surgeons.
J. Huh, J. Chen, F. Kafie, G. Furman, J. Milliken, S. Wilson. 1997. A Multivesicular Liposomal Amikacin Formulation in the Treatment of Prosthetic Vascular Graft Infection. Southwestern Surgical Congress.
J. Huh, J. Chen, C. Malki, F. Kafie, G. Furman, S. Wilson. 1997. Local Treatment of Prosthetic Vascular Graft Infection with Multivesicular Liposome Encapsulated Amikacin. Association of Veteran Surgeons.
F. E. Kafie, R. Williams, D.J. Tessier, G. Tominaga, M. Cinat,, Y. Podnos, M. Lekawa, S.E. Wilson. Serial Abdominal Closure ("SAC") Technique: A Novel Method for Delayed Closure of the Abdominal Wall. Southwestern Surgical Congress.
F.E. Kafie, J.A. Freischlag. The role of pre-operative embolization in Carotid Body Tumors. Southwestern Vascular Society.
Kafie, F, Williams, R. Intra-abdominal Complications of HIV Infection. Surgical Strategies in the AIDS Patient. 1997.
Kafie, F, Williams RA, Wilson SE. Clinical Staging of HIV Infection. In SE Wilson and RA Williams: Surgical Problems in the AIDS Patient. New York, Igaku-Shoin, 1995, pp 31-41.
Kafie, F, Williams RA. Venous Disease in the Elderly. In Aronow WS, Stemmer EA, Wilson SE. Surgical Disease of the Elderly. Futura Publishing Company. 1996.
Kafie, F, (Co-Editor) Surgery-Current Clinical Strategies. Surgical Handbook, Third Edition 1997.
Kafie, F, Wilson SE, Complications of Vascular Access in the Dialysis Patient. Textbook: Vascular Surgery, 1997. Yao.
Kafie, F, Deutsch, LS, Wilson, SE. Balloon Angioplasty of Infra-Inguinal Arterial Occlusive Disease. Textbook: Endovascular Surgery, 1999. Ahn et al.
Kafie, F, Fujitani, RM. Screening and Pre-operative Imaging of Candidates for Carotid Endarterectomy. Textbook: Seminars in Vascular Surgery, 1999. Rutherford et al.
Quinones-Baldrich, W, Kafie, F. Surgical Treatment of Infected Aortic Aneurysms. Textbook. Current Vascular Practice, 1999. Ballard, et al.
Freischlag, J, Kafie, F. Peritoneal dialysis. Vascular Access:Principles and Practice, 2000. Wilson et al.
Kafie, F, Moore, W. Management of Cerebrovascular Disease. The practice of General Surgery, 2000. Bland et al.
Quinones-Baldrich, W, Kafie, F. Thrombolytic Therapy for Vascular Disease. Vascular Surgery. Moore. In progress.
Guest Speaker UCSD School of Medicine 1991
"How to get into Medical School"Harvard Medical School 1992
"Photodynamic Therapy in the treatment
of Head and Neck cancers"American College of Surgeons (SC Chapter) 1994
"Small Cell Carcinoma of the Larynx:
Case Report and Review of the Literature"American Association of Thoracic Surgeons 1995
International Meeting
"The Effect of Lung Volume Reduction Surgery
in a Rabbit Model of Bullous Lung Disease"Society of Thoracic Surgery 1996
International Meeting
"The Effect of Lung Volume Reduction Surgery
in a Rabbit Model of Pulmonary Emphysema"American College of Surgeons (SC Chapter) 1996
"Factors Related to Outcome in Blunt Intestinal
Injuries Requiring Operation"Kaiser Permanente (Anaheim, California) 1996
"Surgical Management of Thyroid Malignancies"Kaiser Permanente (Anaheim, California) 1997
"Controversies in Colorectal Carcinoma"Kaiser Permanente (Anaheim, California) 1997
"Gastroesophageal Reflux Disease"University of California, Irvine (Orange, California) 1998
"Choledocal Cyst: Surgical Management"University of California, Irvine (Orange, California) 1998
"Thoracic Vascular Injuries"University of California, Irvine (Orange, California) 1998
"Biliary Anomalies"University of California, Irvine (Orange, California) 1998
"Cystic Lesions of the Pancreas"University of California, Irvine (Orange, California) 1999
"Thymoma"University of California, Irvine (Orange, California) 1999
"Small Bowel Tumors"The Southwestern Surgical Congress 1999
(San Diego, California)
"Serial Abdominal Closure (ìSACî) Technique:
A Novel Method for Delayed Closure of the Abdominal Wall"University of California, Irvine (Orange, California) 1999
"Liver Trauma"University of California, Irvine (Orange, California) 1999
"Serial Abdominal Closure"University of California, Los Angeles (L.A., California) 1999
"Axillosubclavian Vein Thrombosis"University of California, Los Angeles (L.A., California) 1999
"Chronic Messenteric Ischemia"University of California, Los Angeles (L.A., California) 2000
"Non-Atherosclerotic lesions of Arch Vessels"University of California, Los Angeles (L.A., California) 1999
"Carotid Body Tumors"University of California, Los Angeles (L.A., California) 1999
"Thoracoabdominal Aneurysms"University of California, Los Angeles (L.A., California) 1999
"Endovascular Grafting for AAA"South Calif Endovascular Meeting (L.A., California) 2000
"Endovascular Treatment ofType 1 Endoleak "Southwestern Vasc (Palm Springs, California) 2000
"The Role of Pre-operative Embolization in Carotid Body Tumors"Baptist Medical Center (Pensacola, Florida) 2001-02
"Endovascular Surgery: the future of Vascular Surgery?"
"Thoracic Outlet Syndrome"
"Vascular Access for Hemodialysis"
-Costa Rica Medical Program 1990
description: Observe and participate in clinical
activities in community-based health centers.
Participate in vaccination programs, lectures, and
preventive health care services in the community.
-National Institute of Cardiovascular Technologies 1989
-îPulse Programî (UCI Medical Center) 1989
-Community Clinic of Orange County (UCI) 1985
HOAG Memorial Hospital 1984
Activities & Awards:UCLA School of Medicine
-President for Aesculapians Student Committee 1990
-Co-Chair for Aesculapians Student Dinner Committee 1989
-Massachusetts General Hospital Fellowship 1991
-Member of Admissions Committee 1990
-Member of the California/AMA 1993
-Interamerican College of Physicians & Surgeons 1993
-Fluent in Spanish (speak and write)
Wellman Laser Laboratory Fellowship (Harvard) 1991
Beckman Laser Laboratory Fellowship (California) 1995Golden Scalpel Award- "Best Surgical Resident" 1999
University of California, Irvine
Advanced Trauma Life Support 1997-2001
Advanced Cardiac Life Support
Hyperbaric Medicine Certificate